DHODH Antibody (PACO54734)
- SKU:
- PACO54734
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DHODH Antibody (PACO54734) |
Antibody SKU: | PACO54734 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial protein (241-395AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO54734 at dilution of 1:100. |
Background: | Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. |
Synonyms: | Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase), DHODH |
UniProt Protein Function: | DHODH: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS); also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases. Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. |
UniProt Protein Details: | Protein type:Mitochondrial; EC 1.3.5.2; Nucleotide Metabolism - pyrimidine; Membrane protein, integral; Oxidoreductase Chromosomal Location of Human Ortholog: 16q22 Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion; nucleoplasm Molecular Function:dihydroorotate dehydrogenase activity Biological Process: 'de novo' pyrimidine base biosynthetic process; pyrimidine nucleoside biosynthetic process Disease: Postaxial Acrofacial Dysostosis |
NCBI Summary: | The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q02127 |
NCBI GenInfo Identifier: | 56405372 |
NCBI Gene ID: | 1723 |
NCBI Accession: | Q02127.3 |
UniProt Secondary Accession: | Q02127,Q6P176, A8K8C8, |
UniProt Related Accession: | Q02127 |
Molecular Weight: | 42,867 Da |
NCBI Full Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
NCBI Synonym Full Names: | dihydroorotate dehydrogenase (quinone) |
NCBI Official Symbol: | DHODH |
NCBI Official Synonym Symbols: | URA1; POADS; DHOdehase |
NCBI Protein Information: | dihydroorotate dehydrogenase (quinone), mitochondrial |
UniProt Protein Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
UniProt Synonym Protein Names: | Dihydroorotate oxidase |
UniProt Gene Name: | DHODH |
UniProt Entry Name: | PYRD_HUMAN |
Antibodies |
Anti-DHODH Antibody (CAB13295) |
Anti-DHODH Antibody (CAB6899) |
DHODH Antibody (PACO02586) |
DHODH Antibody (PACO08822) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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