DEFA4 Antibody (PACO19558)
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주문- SKU:
- PACO19558
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DEFA4 Antibody (PACO19558) |
Antibody SKU: | PACO19558 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human DEFA4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19558(DEFA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19558(DEFA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several α defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, α 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. |
Synonyms: | defensin, α 4, corticostatin |
NCBI Summary: | Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014] |
UniProt Code: | P12838 |
NCBI GenInfo Identifier: | 4503303 |
NCBI Gene ID: | 1669 |
NCBI Accession: | NP_001916.1 |
UniProt Related Accession: | P12838 |
Molecular Weight: | ~ 11kDa |
NCBI Full Name: | neutrophil defensin 4 preproprotein |
NCBI Synonym Full Names: | defensin alpha 4 |
NCBI Official Symbol: | DEFA4 |
NCBI Official Synonym Symbols: | HP4; DEF4; HP-4; HNP-4 |
NCBI Protein Information: | neutrophil defensin 4 |
UniProt Protein Name: | Neutrophil defensin 4 |
UniProt Synonym Protein Names: | Defensin, alpha 4; HNP-4 |
Protein Family: | Beta-carotene isomerase |
UniProt Gene Name: | DEFA4 |
UniProt Entry Name: | DEF4_HUMAN |