DEF6 Antibody (PACO49318)
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주문- SKU:
- PACO49318
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DEF6 Antibody (PACO49318) |
Antibody SKU: | PACO49318 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Differentially expressed in FDCP 6 homolog protein (20-114AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Mouse liver tissue, Mouse kidney tissue. All lanes: DEF6 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 74 kDa. Observed band size: 74 kDa.. |
![]() | Immunofluorescent analysis of U251 cells using PACO49318 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). |
Synonyms: | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein), DEF6, IBP |
UniProt Protein Function: | DEF6: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. |
UniProt Protein Details: | Protein type:GEFs, Rac/Rho; GEFs Chromosomal Location of Human Ortholog: 6p21.33-p21.1 Cellular Component: membrane Molecular Function:protein binding |
NCBI Summary: | DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9H4E7 |
NCBI GenInfo Identifier: | 74761430 |
NCBI Gene ID: | 50619 |
NCBI Accession: | Q9H4E7.1 |
UniProt Secondary Accession: | Q9H4E7,Q86VF4, |
UniProt Related Accession: | Q9H4E7 |
Molecular Weight: | 73,910 Da |
NCBI Full Name: | Differentially expressed in FDCP 6 homolog |
NCBI Synonym Full Names: | DEF6, guanine nucleotide exchange factor |
NCBI Official Symbol: | DEF6 |
NCBI Official Synonym Symbols: | IBP; SLAT; SWAP70L |
NCBI Protein Information: | differentially expressed in FDCP 6 homolog |
UniProt Protein Name: | Differentially expressed in FDCP 6 homolog |
UniProt Synonym Protein Names: | IRF4-binding protein |
Protein Family: | Differentially expressed in FDCP |
UniProt Gene Name: | DEF6 |
UniProt Entry Name: | DEFI6_HUMAN |