DDX3Y Antibody (PACO22177)
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주문- SKU:
- PACO22177
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DDX3Y Antibody (PACO22177) |
Antibody SKU: | PACO22177 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human DDX3Y. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry analysis of paraffin-embedded human brain tissue using DDX3Y antibody. |
Background: | Probable ATP-dependent RNA helicase. May play a role in spermatogenesis. |
Synonyms: | ATP-dependent RNA helicase DDX3Y; DBY; DDXY; DEAD (Aspartate-glutamate-alanine-aspartate) box polypeptide; Y chromosome |
UniProt Protein Function: | DDX3Y: a Y-linked DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DBY mutations causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Two alternatively spliced transcripts differ only in the length of the 3' UTR. |
UniProt Protein Details: | Protein type:RNA-binding; EC 3.6.4.13; Helicase Chromosomal Location of Human Ortholog: Yq11 Cellular Component: cytoplasm; membrane Molecular Function:ATP-dependent RNA helicase activity Biological Process: chromosome segregation; regulation of gene expression; RNA secondary structure unwinding; translational initiation Disease: Spermatogenic Failure, Y-linked, 2 |
NCBI Summary: | The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
UniProt Code: | O15523 |
NCBI GenInfo Identifier: | 73620957 |
NCBI Gene ID: | 8653 |
NCBI Accession: | O15523.2 |
UniProt Secondary Accession: | O15523,Q8IYV7, B4DK29, B4DXX7, |
UniProt Related Accession: | O15523 |
Molecular Weight: | 32,416 Da |
NCBI Full Name: | ATP-dependent RNA helicase DDX3Y |
NCBI Synonym Full Names: | DEAD-box helicase 3, Y-linked |
NCBI Official Symbol: | DDX3Y |
NCBI Official Synonym Symbols: | DBY |
NCBI Protein Information: | ATP-dependent RNA helicase DDX3Y |
UniProt Protein Name: | ATP-dependent RNA helicase DDX3Y |
UniProt Synonym Protein Names: | DEAD box protein 3, Y-chromosomal |
Protein Family: | ATP-dependent RNA helicase |
UniProt Gene Name: | DDX3Y |
UniProt Entry Name: | DDX3Y_HUMAN |
Antibodies |
Anti-DDX3Y Antibody (CAB11704) |
Anti-DDX3Y Antibody (CAB14810) |
DDX3Y Antibody (PACO05595) |
DDX3Y Antibody (PACO08792) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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