DCP1A Antibody (PACO44621)
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주문- SKU:
- PACO44621
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DCP1A Antibody (PACO44621) |
Antibody SKU: | PACO44621 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human mRNA-decapping enzyme 1A protein (303-582AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: DCP1A antibody at 1.23µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: 293T whole cell lysate. Lane 3: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 64, 60 kDa. Observed band size: 64, 40 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO44621 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human lung tissue using PACO44621 at dilution of 1:100. |
Background: | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. |
Synonyms: | mRNA-decapping enzyme 1A (EC 3) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF), DCP1A, SMIF |
UniProt Protein Function: | DCP1A: a decapping enzyme. Plays a role in general and regulated mRNA decay. Apparently plays a role in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. May function as a transactivator of SMAD4 that participates in TGF-beta signaling. |
UniProt Protein Details: | Protein type:RNA processing; Transcription, coactivator/corepressor; EC 3.-.-.-; Hydrolase Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: cytosol; intracellular membrane-bound organelle; membrane; nucleus Molecular Function:enzyme activator activity; enzyme regulator activity; hydrolase activity; identical protein binding; mRNA binding; protein binding Biological Process: deadenylation-dependent decapping; deadenylation-independent decapping; gene expression; mRNA catabolic process, deadenylation-dependent decay; mRNA catabolic process, nonsense-mediated decay; positive regulation of catalytic activity; regulation of mRNA stability |
NCBI Summary: | Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
UniProt Code: | Q9NPI6 |
NCBI GenInfo Identifier: | 296434475 |
NCBI Gene ID: | 55802 |
NCBI Accession: | Q9NPI6.2 |
UniProt Secondary Accession: | Q9NPI6,B4DHN9, U3KQM8, |
UniProt Related Accession: | Q9NPI6 |
Molecular Weight: | 59,361 Da |
NCBI Full Name: | mRNA-decapping enzyme 1A |
NCBI Synonym Full Names: | decapping mRNA 1A |
NCBI Official Symbol: | DCP1A |
NCBI Official Synonym Symbols: | SMIF; SMAD4IP1; HSA275986; Nbla00360 |
NCBI Protein Information: | mRNA-decapping enzyme 1A |
UniProt Protein Name: | mRNA-decapping enzyme 1A |
UniProt Synonym Protein Names: | Smad4-interacting transcriptional co-activator; Transcription factor SMIF |
Protein Family: | mRNA-decapping enzyme |
UniProt Gene Name: | DCP1A |
UniProt Entry Name: | DCP1A_HUMAN |