DCK Antibody (PACO49506)
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주문- SKU:
- PACO49506
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DCK Antibody (PACO49506) |
Antibody SKU: | PACO49506 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Deoxycytidine kinase protein (1-79AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human glioma using PACO49506 at dilution of 1:100. |
Background: | Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. |
Synonyms: | Deoxycytidine kinase (dCK) (EC 2.7.1.74), DCK |
UniProt Protein Function: | DCK: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family. |
UniProt Protein Details: | Protein type:Kinase, other; Nucleotide Metabolism - purine; EC 2.7.1.74; Nucleotide Metabolism - pyrimidine Chromosomal Location of Human Ortholog: 4q13.3-q21.1 Cellular Component: cytosol; nucleus Molecular Function:protein homodimerization activity; nucleoside kinase activity; deoxycytidine kinase activity; drug binding; ATP binding Biological Process: pyrimidine base metabolic process; pyrimidine nucleotide metabolic process; nucleotide biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; phosphorylation; purine salvage; purine base metabolic process; deoxyribonucleoside monophosphate biosynthetic process |
NCBI Summary: | Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008] |
UniProt Code: | P27707 |
NCBI GenInfo Identifier: | 118447 |
NCBI Gene ID: | 1633 |
NCBI Accession: | P27707.1 |
UniProt Secondary Accession: | P27707,Q5TZY7, Q6FI11, B2R8V6, |
UniProt Related Accession: | P27707 |
Molecular Weight: | 260 |
NCBI Full Name: | Deoxycytidine kinase |
NCBI Synonym Full Names: | deoxycytidine kinase |
NCBI Official Symbol: | DCK |
NCBI Protein Information: | deoxycytidine kinase; deoxynucleoside kinase |
UniProt Protein Name: | Deoxycytidine kinase |
Protein Family: | Deoxycytidine kinase |
UniProt Gene Name: | DCK |
UniProt Entry Name: | DCK_HUMAN |
Antibodies | ELISA Kits |
Anti-DCK Antibody (CAB1794) | Human Deoxycytidine kinase (DCK) ELISA Kit |
DCK Antibody (PACO08757) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |