DAD1 Antibody (PACO08735)
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주문- SKU:
- PACO08735
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | DAD1 Antibody (PACO08735) |
Antibody SKU: | PACO08735 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human DAD1 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | 12kd; |
UniProt Protein Function: | DAD1: Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis. Belongs to the DAD/OST2 family. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Glycan Metabolism - N-glycan biosynthesis; EC 2.4.99.18; Transferase; Membrane protein, multi-pass; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: endoplasmic reticulum membrane; membrane; oligosaccharyl transferase complex; integral to membrane Molecular Function:dolichyl-diphosphooligosaccharide-protein glycotransferase activity; oligosaccharyl transferase activity Biological Process: response to drug; blastocyst development; cellular protein metabolic process; apoptosis; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; response to nutrient; negative regulation of apoptosis |
NCBI Summary: | DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61803 |
NCBI GenInfo Identifier: | 48428858 |
NCBI Gene ID: | 1603 |
NCBI Accession: | P61803.3 |
UniProt Secondary Accession: | P61803,O08552, O70364, P46966, P46968, Q6FGA3, Q96GB7 D3DS25, |
UniProt Related Accession: | P61803 |
Molecular Weight: | 12,497 Da |
NCBI Full Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 |
NCBI Synonym Full Names: | defender against cell death 1 |
NCBI Official Symbol: | DAD1 |
NCBI Official Synonym Symbols: | OST2 |
NCBI Protein Information: | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; DAD-1; oligosaccharyltransferase 2 homolog; oligosaccharyl transferase subunit DAD1; oligosaccharyltransferase subunit 2 (non-catalytic) |
UniProt Protein Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 |
UniProt Synonym Protein Names: | Defender against cell death 1; DAD-1 |
Protein Family: | DASH complex |
UniProt Gene Name: | DAD1 |
UniProt Entry Name: | DAD1_HUMAN |