CYP7A1 Antibody (PACO60673)
- SKU:
- PACO60673
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CYP7A1 Antibody (PACO60673) |
Antibody SKU: | PACO60673 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cholesterol 7-alpha-monooxygenase protein (303-423AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate. All lanes: CYP7A1 antibody at 4.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 58 kDa. Observed band size: 58 kDa. | |
IHC image of PACO60673 diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Catalyzes a rate-limiting step in cholesterol catabolism and bile acid, biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. |
Synonyms: | Cholesterol 7-alpha-monooxygenase (EC 1.14.14.23) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cytochrome P450 7A1), CYP7A1, CYP7 |
UniProt Protein Function: | CYP7A1: Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. Belongs to the cytochrome P450 family. |
UniProt Protein Details: | Protein type:EC 1.14.13.17; Lipid Metabolism - primary bile acid biosynthesis; Endoplasmic reticulum; Oxidoreductase Chromosomal Location of Human Ortholog: 8q11-q12 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle Molecular Function:cholesterol 7-alpha-monooxygenase activity Biological Process: bile acid biosynthetic process; cholesterol catabolic process; cholesterol homeostasis; sterol metabolic process |
NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010] |
UniProt Code: | P22680 |
NCBI GenInfo Identifier: | 544084 |
NCBI Gene ID: | 1581 |
NCBI Accession: | P22680.2 |
UniProt Secondary Accession: | P22680,P78454, Q3MIL8, Q7KZ19, |
UniProt Related Accession: | P22680 |
Molecular Weight: | 57,661 Da |
NCBI Full Name: | Cholesterol 7-alpha-monooxygenase |
NCBI Synonym Full Names: | cytochrome P450 family 7 subfamily A member 1 |
NCBI Official Symbol: | CYP7A1 |
NCBI Official Synonym Symbols: | CP7A; CYP7; CYPVII |
NCBI Protein Information: | cholesterol 7-alpha-monooxygenase |
UniProt Protein Name: | Cholesterol 7-alpha-monooxygenase |
UniProt Synonym Protein Names: | CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1 |
Protein Family: | Cholesterol 7-alpha-monooxygenase |
UniProt Gene Name: | CYP7A1 |
UniProt Entry Name: | CP7A1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |