CYP2B6 Antibody (PACO19539)
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주문- SKU:
- PACO19539
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CYP2B6 Antibody (PACO19539) |
Antibody SKU: | PACO19539 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human CYP2B6 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human colon cancer tissue, Primary antibody: PACO19539(CYP2B6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 4 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19539(CYP2B6 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. |
Synonyms: | cytochrome P450, family 2, subfamily B, polypeptide 6 |
UniProt Protein Function: | CYP2B6: cytochrome P450, subfamily IIB. Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Phosphorylation is accompanied by a decrease in enzyme activity. |
UniProt Protein Details: | Protein type:Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.14.1; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: endoplasmic reticulum membrane Molecular Function:arachidonic acid epoxygenase activity; heme binding; monooxygenase activity; oxygen binding; steroid hydroxylase activity Biological Process: drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; ketone metabolic process; steroid metabolic process; xenobiotic metabolic process Disease: Efavirenz, Poor Metabolism Of |
NCBI Summary: | This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] |
UniProt Code: | P20813 |
NCBI GenInfo Identifier: | 117205 |
NCBI Gene ID: | 1555 |
NCBI Accession: | P20813.1 |
UniProt Secondary Accession: | P20813,Q2V565, Q9UK46, B4DWP3, |
UniProt Related Accession: | P20813 |
Molecular Weight: | 33,385 Da |
NCBI Full Name: | Cytochrome P450 2B6 |
NCBI Synonym Full Names: | cytochrome P450 family 2 subfamily B member 6 |
NCBI Official Symbol: | CYP2B6 |
NCBI Official Synonym Symbols: | CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6 |
NCBI Protein Information: | cytochrome P450 2B6 |
UniProt Protein Name: | Cytochrome P450 2B6 |
UniProt Synonym Protein Names: | 1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1 |
Protein Family: | Cytochrome |
UniProt Gene Name: | CYP2B6 |
UniProt Entry Name: | CP2B6_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |