CYP26B1 Antibody (PACO07288)
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주문- SKU:
- PACO07288
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CYP26B1 Antibody (PACO07288) |
Antibody SKU: | PACO07288 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:10000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide from human protein at AA range: 391-440 |
Form: | Liquid |
Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot analysis of mouse-brain cells using Antibody diluted at 800. Secondary antibody was diluted at 1:20000. |
Synonyms: | CYP26B1 CYP26A2 P450RAI2 |
UniProt Protein Function: | CYP26B1: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Defects in CYP26B1 are the cause of radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA). A disease characterized by craniofacial malformations, occipital encephalocele, radiohumeral fusions, oligodactyly, advanced osseous maturation, and calvarial mineralization defects. Belongs to the cytochrome P450 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell development/differentiation; Cofactor and Vitamin Metabolism - retinol; EC 1.14.-.-; Oxidoreductase Chromosomal Location of Human Ortholog: 2p13.2 Cellular Component: cytoplasm; endoplasmic reticulum membrane Molecular Function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; retinoic acid 4-hydroxylase activity; retinoic acid binding Biological Process: cell fate determination; embryonic limb morphogenesis; male meiosis; negative regulation of retinoic acid receptor signaling pathway; proximal/distal pattern formation; spermatogenesis; sterol metabolic process; vitamin metabolic process; xenobiotic metabolic process Disease: Radiohumeral Fusions With Other Skeletal And Craniofacial Anomalies |
NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] |
UniProt Code: | Q9NR63 |
NCBI GenInfo Identifier: | 20137526 |
NCBI Gene ID: | 56603 |
NCBI Accession: | Q9NR63.1 |
UniProt Secondary Accession: | Q9NR63,Q32MC0, Q53TW1, Q9NP41, B2R8M7, B7Z2K6, B7Z2P4 B7Z3B8, E4W5W7, |
UniProt Related Accession: | Q9NR63 |
Molecular Weight: | 58kDa |
NCBI Full Name: | Cytochrome P450 26B1 |
NCBI Synonym Full Names: | cytochrome P450 family 26 subfamily B member 1 |
NCBI Official Symbol: | CYP26B1 |
NCBI Official Synonym Symbols: | RHFCA; CYP26A2; P450RAI2; P450RAI-2 |
NCBI Protein Information: | cytochrome P450 26B1 |
UniProt Protein Name: | Cytochrome P450 26B1 |
UniProt Synonym Protein Names: | Cytochrome P450 26A2; Cytochrome P450 retinoic acid-inactivating 2; Cytochrome P450RAI-2; Retinoic acid-metabolizing cytochrome |
Protein Family: | Cytochrome |
UniProt Gene Name: | CYP26B1 |