ctxB Recombinant Protein (RPPB3309)

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SKU:
RPPB3309
Product type:
Recombinant Protein
Size:
100ug
Target:
ctxB
Synonyms:
Cholera enterotoxin subunit B
Synonyms:
Cholera enterotoxin B chain
Synonyms:
Cholera enterotoxin gamma chain
Synonyms:
Choleragenoid
Source:
Escherichia Coli
Uniprot:
P01556
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Description

Product Name:ctxB Recombinant Protein
Product Code:RPPB3309
Size:100ug
Target:ctxB
Synonyms:Cholera enterotoxin subunit B, Cholera enterotoxin B chain, Cholera enterotoxin gamma chain, Choleragenoid, ctxB, toxB.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:ctxB is supplied as a 0.2 ?m filtered solution conteining 5mM PB, pH 7.0, 75mM NaCl, and 50 % glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:TPQNITDLCA EYHNTQIYTL NDKIFSYTES LAGKREMAII TFKNGAIFQV EVPGSQHIDS QKKAIERMKD TLRIAYLTEA KVEKLCVWNN KTPHAIAAIS MAN
UniProt Code:P01556

Cholera Toxin B subunit (ctxB) Cholera is a protein complex secreted by the bacterium Vibrio cholerae. ctxB is responsible for the massive, watery diarrhea characteristic of cholera infection. The cholera toxin is an oligomeric complex made up of 6 protein subunits: a single copy of the A subunit and5 copies of the B subunit, denoted as AB5. Subunit B binds while subunit A activates the G protein which activates adenylate cyclase. The five B subunits form a five-membered ring. The A subunit has 2 important segments. The A1 portion of the chain (CTA1) is a globular enzyme payload that ADP-ribosylates G proteins, while the A2 chain (CTA2) forms an extended alpha helix which sits snugly in the central pore of the B subunit ring.

Cholera Toxin B subunit Recombinant produced in E.Coli is a single, non- glycosylated polypeptide chain containing 103 amino acids and having a molecular mass of 11.6kDa.ctxB is purified by proprietary chromatographic techniques.

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