CTNND2 Antibody (PACO47242)
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주문- SKU:
- PACO47242
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CTNND2 Antibody (PACO47242) |
Antibody SKU: | PACO47242 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Catenin delta-2 protein (4-308AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human glioma using PACO47242 at dilution of 1:100. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO47242 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. |
Synonyms: | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin), CTNND2, NPRAP |
UniProt Protein Function: | CTNND2: Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33. Binds to PSEN1. Interacts with RGNEF. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Predominantly expressed in brain; accumulates in cortical neurons. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 5p15.2 Cellular Component: cytoplasm; perikaryon Molecular Function:beta-catenin binding; protein binding Biological Process: cell adhesion; signal transduction; synapse organization and biogenesis Disease: Cri-du-chat Syndrome |
NCBI Summary: | This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] |
UniProt Code: | Q9UQB3 |
NCBI GenInfo Identifier: | 84028193 |
NCBI Gene ID: | 1501 |
NCBI Accession: | Q9UQB3.3 |
UniProt Secondary Accession: | Q9UQB3,O00379, O15390, O43206, O43840, Q13589, Q9UM66 Q9UPM3, B0FTZ7, |
UniProt Related Accession: | Q9UQB3 |
Molecular Weight: | 126,529 Da |
NCBI Full Name: | Catenin delta-2 |
NCBI Synonym Full Names: | catenin delta 2 |
NCBI Official Symbol: | CTNND2 |
NCBI Official Synonym Symbols: | GT24; NPRAP |
NCBI Protein Information: | catenin delta-2 |
UniProt Protein Name: | Catenin delta-2 |
UniProt Synonym Protein Names: | Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; NPRAP; Neurojungin |
Protein Family: | Catenin |
UniProt Gene Name: | CTNND2 |
UniProt Entry Name: | CTND2_HUMAN |
Antibodies |
Anti-CTNND2 Antibody (CAB12633) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |