CTNNA1/CTNNA2 Antibody (PACO00525)
- SKU:
- PACO00525
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CTNNA1/CTNNA2 Antibody |
| Antibody SKU: | PACO00525 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the C-terminal region of human Catenin-alpha E/N. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CTNNA1; Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13; CTNNA2; CAPR; Catenin alpha-2; Alpha N-catenin; Alpha-catenin-related protein |
| UniProt Protein Function: | CTNNA1: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4 and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma- catenin/JUP; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F- actin by other proteins such as LIMA1. Interacts with ARHGAP21 and with AJUBA. Interacts with LIMA1. Expressed ubiquitously in normal tissues. Belongs to the vinculin/alpha-catenin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: focal adhesion; lamellipodium; acrosome; plasma membrane; catenin complex; zonula adherens; intercellular junction; cytosol; actin cytoskeleton Molecular Function:actin filament binding; protein binding; cadherin binding; gamma-catenin binding; beta-catenin binding; structural molecule activity; vinculin binding Biological Process: intercellular junction assembly and maintenance; apical junction assembly; gap junction assembly; protein heterooligomerization; axon regeneration; male gonad development; establishment and/or maintenance of cell polarity; actin filament organization; odontogenesis of dentine-containing teeth; muscle cell differentiation; negative regulation of neuroblast proliferation; ovarian follicle development; response to estrogen stimulus; positive regulation of smoothened signaling pathway; positive regulation of muscle cell differentiation; cell adhesion; vascular endothelial growth factor receptor signaling pathway; aging |
| UniProt Code: | P35221 |
| NCBI GenInfo Identifier: | 461853 |
| NCBI Gene ID: | 1495 |
| NCBI Accession: | P35221.1 |
| UniProt Secondary Accession: | P35221,Q12795, Q8N1C0, |
| UniProt Related Accession: | P35221 |
| Molecular Weight: | 59,550 Da |
| NCBI Full Name: | Catenin alpha-1 |
| NCBI Synonym Full Names: | catenin (cadherin-associated protein), alpha 1, 102kDa |
| NCBI Official Symbol: | CTNNA1 |
| NCBI Official Synonym Symbols: | CAP102 |
| NCBI Protein Information: | catenin alpha-1; alpha-catenin; alphaE-catenin; alpha E-catenin; alpha-E-catenin; renal carcinoma antigen NY-REN-13; cadherin-associated protein,102kDa |
| UniProt Protein Name: | Catenin alpha-1 |
| UniProt Synonym Protein Names: | Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13 |
| Protein Family: | Catenin |
| UniProt Gene Name: | CTNNA1 |
| UniProt Entry Name: | CTNA1_HUMAN |
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