CST4 Antibody (PACO43716)
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주문- SKU:
- PACO43716
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CST4 Antibody (PACO43716) |
Antibody SKU: | PACO43716 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cystatin-S protein (21-141AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43716 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human salivary pland tissue using PACO43716 at dilution of 1:100. |
Background: | This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively. |
Synonyms: | Cystatin-S (Cystatin-4) (Cystatin-SA-III) (Salivary acid, c protein 1), CST4 |
UniProt Protein Function: | CST4: This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively. Belongs to the cystatin family. |
UniProt Protein Details: | Protein type:Inhibitor; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20p11.21 Cellular Component: extracellular space Molecular Function:cysteine protease inhibitor activity; protease binding Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of proteolysis; retinal homeostasis |
NCBI Summary: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function. [provided by RefSeq, Jul 2008] |
UniProt Code: | P01036 |
NCBI GenInfo Identifier: | 4503109 |
NCBI Gene ID: | 1472 |
NCBI Accession: | |
UniProt Secondary Accession: | P01036,Q9UBI5, Q9UCS9, |
UniProt Related Accession: | P01036 |
Molecular Weight: | 16,214 Da |
NCBI Full Name: | cystatin-S |
NCBI Synonym Full Names: | cystatin S |
NCBI Official Symbol: | CST4 |
NCBI Protein Information: | cystatin-S |
UniProt Protein Name: | Cystatin-S |
UniProt Synonym Protein Names: | Cystatin-4; Cystatin-SA-III; Salivary acidic protein 1 |
Protein Family: | Cystatin |
UniProt Gene Name: | CST4 |
UniProt Entry Name: | CYTS_HUMAN |
Antibodies |
Anti-Cystatin-S Antibody (CAB8114) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |