CSNK1G2 Antibody (PACO44755)
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주문- SKU:
- PACO44755
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CSNK1G2 Antibody (PACO44755) |
Antibody SKU: | PACO44755 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Casein kinase I isoform gamma-2 protein (316-415AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CSNK1G2 antibody at 4.21µg/ml. Lane 1: Mouse gonadal tissue. Lane 2: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa.. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO44755 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44755 at dilution of 1:100. |
Background: | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acid, c proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-β responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. |
Synonyms: | Casein kinase I isoform gamma-2 (CKI-γ 2) (EC 2.7.11.1), CSNK1G2, CK1G2 |
UniProt Protein Function: | CK1G2: an ubiquitous protein kinase of the CK1 family. Involved in growth and morphogenesis. Two splice variant isoforms have been described. |
UniProt Protein Details: | Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; CK1 group; CK1 family Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: membrane; cytosol; nucleus Molecular Function:protein serine/threonine kinase activity; protein binding; magnesium ion binding; phosphoprotein binding; glycoprotein binding; peptide binding; ATP binding Biological Process: regulation of cell shape; peptidyl-serine phosphorylation; sphingolipid metabolic process; Wnt receptor signaling pathway; sphingolipid biosynthetic process; protein amino acid autophosphorylation; endocytosis; signal transduction; protein amino acid phosphorylation |
UniProt Code: | P78368 |
NCBI GenInfo Identifier: | 3024060 |
NCBI Gene ID: | 1455 |
NCBI Accession: | P78368.1 |
UniProt Secondary Accession: | P78368,O00704, Q8WUB1, B5BU42, |
UniProt Related Accession: | P78368 |
Molecular Weight: | 415 |
NCBI Full Name: | Casein kinase I isoform gamma-2 |
NCBI Synonym Full Names: | casein kinase 1, gamma 2 |
NCBI Official Symbol: | CSNK1G2 |
NCBI Official Synonym Symbols: | CK1g2 |
NCBI Protein Information: | casein kinase I isoform gamma-2; CKI-gamma 2; casein kinase 1 isoform gamma-2 |
UniProt Protein Name: | Casein kinase I isoform gamma-2 |
Protein Family: | Casein kinase |
UniProt Gene Name: | CSNK1G2 |
UniProt Entry Name: | KC1G2_HUMAN |
Antibodies | ELISA Kits |
Anti-CSNK1G2 Antibody (CAB7326) | CKI-gamma2 Colorimetric Cell-Based ELISA |
CSNK1G2 Antibody (PACO02496) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |