CSF2RA Antibody (PACO18010)
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주문- SKU:
- PACO18010
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CSF2RA Antibody (PACO18010) |
Antibody SKU: | PACO18010 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human CSF2RA |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18010(CSF2RA Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue, HepG2 cells, Primary antibody: PACO18010(CSF2RA Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18010(CSF2RA Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is the α subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. |
Synonyms: | colony stimulating factor 2 receptor, alpha, low-affinity |
UniProt Protein Function: | CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3 Cellular Component: extracellular region; integral to plasma membrane; intracellular; plasma membrane Molecular Function:granulocyte colony-stimulating factor binding; granulocyte colony-stimulating factor receptor activity; protein binding; receptor activity Biological Process: activation of MAPKK activity; axon guidance; cellular protein metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4 |
NCBI Summary: | The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008] |
UniProt Code: | P15509 |
NCBI GenInfo Identifier: | 121509 |
NCBI Gene ID: | 1438 |
NCBI Accession: | P15509.1 |
UniProt Secondary Accession: | P15509,O00207, Q14429, Q14430, Q14431, Q16564, A7J003 A8KAM1, B4DW68, J3JS76, J3JS77, |
UniProt Related Accession: | P15509 |
Molecular Weight: | 31,101 Da |
NCBI Full Name: | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
NCBI Synonym Full Names: | colony stimulating factor 2 receptor alpha subunit |
NCBI Official Symbol: | CSF2RA |
NCBI Official Synonym Symbols: | GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha |
NCBI Protein Information: | granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
UniProt Protein Name: | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
UniProt Synonym Protein Names: | CDw116; CD_antigen: CD116 |
Protein Family: | Granulocyte-macrophage colony-stimulating factor receptor |
UniProt Gene Name: | CSF2RA |
UniProt Entry Name: | CSF2R_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |