CRHR2 Antibody (PACO19510)
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주문- SKU:
- PACO19510
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CRHR2 Antibody (PACO19510) |
Antibody SKU: | PACO19510 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human CRHR2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19510(CRHR2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: NIH/3T3 cells, mouse brain tissue, Primary antibody: PACO19510(CRHR2 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19510(CRHR2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Synonyms: | corticotropin releasing hormone receptor 2 |
UniProt Protein Function: | CRHR2: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:corticotrophin-releasing factor receptor activity; protein binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger |
NCBI Summary: | The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011] |
UniProt Code: | Q13324 |
NCBI GenInfo Identifier: | 6226847 |
NCBI Gene ID: | 1395 |
NCBI Accession: | Q13324.2 |
UniProt Secondary Accession: | Q13324,O43461, Q4QRJ4, Q99431, B2R967, B3SXS6, B3SXS7 B3SXS8, B3SXT0, F8WA81, |
UniProt Related Accession: | Q13324 |
Molecular Weight: | 47,560 Da |
NCBI Full Name: | Corticotropin-releasing factor receptor 2 |
NCBI Synonym Full Names: | corticotropin releasing hormone receptor 2 |
NCBI Official Symbol: | CRHR2 |
NCBI Official Synonym Symbols: | CRF2; CRFR2; CRF-RB; HM-CRF |
NCBI Protein Information: | corticotropin-releasing factor receptor 2 |
UniProt Protein Name: | Corticotropin-releasing factor receptor 2 |
UniProt Synonym Protein Names: | Corticotropin-releasing hormone receptor 2; CRH-R-2; CRH-R2 |
Protein Family: | Corticotropin-releasing factor receptor |
UniProt Gene Name: | CRHR2 |
UniProt Entry Name: | CRFR2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |