CRHR1 Antibody (PACO19508)
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주문- SKU:
- PACO19508
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CRHR1 Antibody (PACO19508) |
Antibody SKU: | PACO19508 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human CRHR1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19508(CRHR1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. |
Synonyms: | corticotropin releasing hormone receptor 1 |
UniProt Protein Function: | CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2 Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane Molecular Function:corticotrophin-releasing factor receptor activity; protein binding Biological Process: adenylate cyclase activation; adrenocorticotropin hormone secretion; immune response; parturition |
NCBI Summary: | This locus represents naturally occurring readthrough transcription between neighboring GeneID:401884 (ADP-ribosylation factor 3 pseudogene) and GeneID:1394 (CRHR1, corticotropin releasing hormone receptor 1) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Code: | P34998 |
NCBI GenInfo Identifier: | 461836 |
NCBI Gene ID: | 104909134 |
NCBI Accession: | P34998.1 |
UniProt Secondary Accession: | P34998,Q13008, Q4QRJ1, Q9UK64, B4DIE9, |
Molecular Weight: | 28,122 Da |
NCBI Full Name: | Corticotropin-releasing factor receptor 1 |
NCBI Official Symbol: | MGC57346-CRHR1 |
NCBI Protein Information: | MGC57346-CRHR1 protein |
UniProt Protein Name: | Corticotropin-releasing factor receptor 1 |
UniProt Synonym Protein Names: | Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1 |
Protein Family: | Corticotropin-releasing factor receptor |
UniProt Gene Name: | CRHR1 |
UniProt Entry Name: | CRFR1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |