CPEB1 Antibody (PACO40370)
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주문- SKU:
- PACO40370
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CPEB1 Antibody (PACO40370) |
Antibody SKU: | PACO40370 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cytoplasmic polyadenylation element-binding protein 1 protein (1-486AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. |
Synonyms: | Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1), CPEB1, CPEB |
UniProt Protein Function: | CPEB: cytoplasmic polyadenylation element binding protein 1. Binds to the protein CPE and drives its polyadenylation. Activated by the protein kinase AurA. Insulin and progesterone stimulate AurA-catalyzed phosphorylation of CPEB in oocytes. Neuronal CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. |
UniProt Protein Details: | Protein type:Translation; RNA-binding Chromosomal Location of Human Ortholog: 15q25.2 Cellular Component: postsynaptic membrane; dendrite; postsynaptic density; cytoplasm; nucleus; cell junction Molecular Function:metal ion binding; translation repressor activity, nucleic acid binding; nucleotide binding Biological Process: synaptonemal complex assembly; cellular response to insulin stimulus; mRNA processing; regulation of neuronal synaptic plasticity |
NCBI Summary: | This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
UniProt Code: | Q9BZB8 |
NCBI GenInfo Identifier: | 74762720 |
NCBI Gene ID: | 64506 |
NCBI Accession: | Q9BZB8.1 |
UniProt Secondary Accession: | Q9BZB8,P70166, P0C279, |
UniProt Related Accession: | Q9BZB8 |
Molecular Weight: | 53,635 Da |
NCBI Full Name: | Cytoplasmic polyadenylation element-binding protein 1 |
NCBI Synonym Full Names: | cytoplasmic polyadenylation element binding protein 1 |
NCBI Official Symbol: | CPEB1 |
NCBI Official Synonym Symbols: | CPEB; CPEB-1; CPE-BP1; hCPEB-1 |
NCBI Protein Information: | cytoplasmic polyadenylation element-binding protein 1; CPE-binding protein 1 |
UniProt Protein Name: | Cytoplasmic polyadenylation element-binding protein 1 |
Protein Family: | C-phycoerythrin |
UniProt Gene Name: | CPEB1 |
UniProt Entry Name: | CPEB1_HUMAN |