CPE Antibody (PACO22238)
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주문- SKU:
- PACO22238
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CPE Antibody (PACO22238) |
Antibody SKU: | PACO22238 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human CPE. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from 3T3 cells and RAW264.7cells, using CPE antibody. |
Background: | Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. |
Synonyms: | carboxypeptidase e; carboxypeptidase e preproprotein; cbpe; cpe; |
UniProt Protein Function: | CPE: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; EC 3.4.17.10; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q32.3 Cellular Component: cell soma; extracellular space; Golgi apparatus; plasma membrane; secretory granule; secretory granule membrane Molecular Function:carboxypeptidase activity; cell adhesion molecule binding; metallocarboxypeptidase activity; neurexin binding; serine carboxypeptidase activity Biological Process: insulin processing; metabolic process; Wnt receptor signaling pathway |
NCBI Summary: | This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015] |
UniProt Code: | P16870 |
NCBI GenInfo Identifier: | 115892 |
NCBI Gene ID: | 1363 |
NCBI Accession: | P16870.1 |
UniProt Secondary Accession: | P16870,Q9UIU9, A8K4N1, B3KR42, B4DFN4, D3DP33, |
UniProt Related Accession: | P16870 |
Molecular Weight: | 49,886 Da |
NCBI Full Name: | Carboxypeptidase E |
NCBI Synonym Full Names: | carboxypeptidase E |
NCBI Official Symbol: | CPE |
NCBI Official Synonym Symbols: | CPH |
NCBI Protein Information: | carboxypeptidase E |
UniProt Protein Name: | Carboxypeptidase E |
UniProt Synonym Protein Names: | Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase |
Protein Family: | Carboxypeptidase |
UniProt Gene Name: | CPE |
UniProt Entry Name: | CBPE_HUMAN |
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