COPS3 Antibody (PACO44464)
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주문- SKU:
- PACO44464
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | COPS3 Antibody (PACO44464) |
Antibody SKU: | PACO44464 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human COP9 signalosome complex subunit 3 protein (194-423AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: COPS3 antibody at 3.41µg/ml. Lane 1: MCF-7 whole cell lysate. Lane 2: Hela whole cell lysate. Lane 3: 293T whole cell lysate. Lane 4: HT29 whole cell lysate. Lane 5: Mouse heart tissue. Lane 6: Mouse brain tissue. Lane 7: Mouse ovarian tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 48, 46 kDa. Observed band size: 46 kDa.. | |
Immunohistochemistry of paraffin-embedded human heart tissue using PACO44464 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44464 at dilution of 1:100. |
Background: | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
Synonyms: | COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3), COPS3, CSN3 |
UniProt Protein Function: | COPS3: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN3 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: nucleoplasm; signalosome; cytoplasm; nucleus Molecular Function:protein binding Biological Process: ubiquitin-dependent protein catabolic process; response to light stimulus; cullin deneddylation; in utero embryonic development; signal transduction |
NCBI Summary: | The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
UniProt Code: | Q9UNS2 |
NCBI GenInfo Identifier: | 55976621 |
NCBI Gene ID: | 8533 |
NCBI Accession: | Q9UNS2.3 |
UniProt Secondary Accession: | Q9UNS2,O43191, Q7LDR6, B2R683, B4DY81, |
UniProt Related Accession: | Q9UNS2 |
Molecular Weight: | 423 |
NCBI Full Name: | COP9 signalosome complex subunit 3 |
NCBI Synonym Full Names: | COP9 signalosome subunit 3 |
NCBI Official Symbol: | COPS3 |
NCBI Official Synonym Symbols: | CSN3; SGN3 |
NCBI Protein Information: | COP9 signalosome complex subunit 3; signalosome subunit 3; COP9 complex subunit 3; JAB1-containing signalosome subunit 3; COP9 constitutive photomorphogenic homolog subunit 3 |
UniProt Protein Name: | COP9 signalosome complex subunit 3 |
UniProt Synonym Protein Names: | JAB1-containing signalosome subunit 3 |
UniProt Gene Name: | COPS3 |
UniProt Entry Name: | CSN3_HUMAN |
Antibodies | ELISA Kits |
Anti-COPS3 Antibody (CAB7017) | JAB1 Colorimetric Cell-Based ELISA Kit |
COPS3 Antibody (PACO06380) | |
COPS3 Antibody (PACO08525) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |