COPS2 Antibody (PACO43237)
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주문- SKU:
- PACO43237
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | COPS2 Antibody (PACO43237) |
Antibody SKU: | PACO43237 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human COP9 signalosome complex subunit 2 protein (1-310AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human skin tissue using PACO43237 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO43237 at dilution of 1:100. |
Background: | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. |
Synonyms: | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15), COPS2, CSN2 TRIP15 |
UniProt Protein Function: | COPS2: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Belongs to the CSN2 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q21.2 Cellular Component: cytoplasm; nucleoplasm; signalosome Molecular Function:protein binding Biological Process: cullin deneddylation; nucleotide-excision repair, DNA damage recognition; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair |
UniProt Code: | P61201 |
NCBI GenInfo Identifier: | 47117681 |
NCBI Gene ID: | 9318 |
NCBI Accession: | P61201.1 |
UniProt Secondary Accession: | P61201,O88950, Q15647, Q6FGP4, Q9BY54, Q9R249, Q9UNI2 Q9UNQ5, |
UniProt Related Accession: | P61201 |
Molecular Weight: | 52,405 Da |
NCBI Full Name: | COP9 signalosome complex subunit 2 |
NCBI Synonym Full Names: | COP9 signalosome subunit 2 |
NCBI Official Symbol: | COPS2 |
NCBI Official Synonym Symbols: | CSN2; SGN2; ALIEN; TRIP15 |
NCBI Protein Information: | COP9 signalosome complex subunit 2 |
UniProt Protein Name: | COP9 signalosome complex subunit 2 |
UniProt Synonym Protein Names: | Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 |
UniProt Gene Name: | COPS2 |
UniProt Entry Name: | CSN2_HUMAN |
Antibodies | ELISA Kits |
Anti-COPS2 Antibody (CAB7037) | COPS2 Colorimetric Cell-Based ELISA |
COPS2 Antibody (PACO05743) | |
COPS2 Antibody (PACO08524) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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