COPB2 Antibody (PACO44494)
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주문- SKU:
- PACO44494
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | COPB2 Antibody (PACO44494) |
Antibody SKU: | PACO44494 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Coatomer subunit beta' protein (657-906AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: COPB2 antibody at 2.51µg/ml. Lane 1: Human placenta tissue. Lane 2: MCF-7 whole cell lysate. Lane 3: Hela whole cell lysate. Lane 4: HepG2 whole cell lysate. Lane 5: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 103, 100 kDa. Observed band size: 103 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO44494 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO44494 at dilution of 1:100. |
Background: | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). |
Synonyms: | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102), COPB2 |
UniProt Protein Function: | COPB2: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the WD repeat COPB2 family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Vesicle Chromosomal Location of Human Ortholog: 3q23 Cellular Component: COPI vesicle coat; cytosol; endoplasmic reticulum membrane; Golgi membrane; transport vesicle Molecular Function:protein binding Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to ER |
NCBI Summary: | The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM, Jul 2002] |
UniProt Code: | P35606 |
NCBI GenInfo Identifier: | 544076 |
NCBI Gene ID: | 9276 |
NCBI Accession: | P35606.2 |
UniProt Secondary Accession: | P35606,B4DZI8, |
UniProt Related Accession: | P35606 |
Molecular Weight: | 99,046 Da |
NCBI Full Name: | Coatomer subunit beta' |
NCBI Synonym Full Names: | coatomer protein complex subunit beta 2 |
NCBI Official Symbol: | COPB2 |
NCBI Official Synonym Symbols: | beta'-COP |
NCBI Protein Information: | coatomer subunit beta' |
UniProt Protein Name: | Coatomer subunit beta' |
UniProt Synonym Protein Names: | Beta'-coat protein; Beta'-COP; p102 |
UniProt Gene Name: | COPB2 |
UniProt Entry Name: | COPB2_HUMAN |
Antibodies |
Anti-COPB2 Antibody (CAB7036) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |