COL4A5 Antibody (PACO23312)
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주문- SKU:
- PACO23312
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | COL4A5 Antibody (PACO23312) |
Antibody SKU: | PACO23312 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:100, IF:1:100-1:500 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human Collagen IV alpha 5. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Collagen IV alpha 5 antibody. |
![]() | Immunofluorescence analysis of HeLa cells, using Collagen IV alpha 5 antibody. |
Background: | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. |
Synonyms: | Collagen alpha-5(IV) chain ; CO4A5; |
UniProt Protein Function: | COL4A5: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A5 are the cause of Alport syndrome X- linked (APSX). APSX is characterized by progressive glomerulonephritis, renal failure, sensorineural deafness, specific eye abnormalities (lenticonous and macular flecks), and glomerular basement membrane defects. The disorder shows considerable heterogeneity in that families differ in the age of end-stage renal disease and the occurrence of deafness. Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are found in the chromosome Xq22.3 centromeric deletion syndrome. This results in a phenotype with features of diffuse leiomyomatosis and Alport syndrome (DL-ATS). Belongs to the type IV collagen family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Extracellular matrix; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xq22 Cellular Component: endoplasmic reticulum lumen; extracellular region Biological Process: collagen catabolic process; extracellular matrix organization and biogenesis Disease: Alport Syndrome, X-linked |
UniProt Code: | P29400 |
NCBI GenInfo Identifier: | 461675 |
NCBI Gene ID: | 1287 |
NCBI Accession: | P29400.2 |
UniProt Secondary Accession: | P29400,Q16006, Q16126, Q6LD84, Q7Z700, Q9NUB7, |
Molecular Weight: | 161,632 Da |
NCBI Full Name: | Collagen alpha-5(IV) chain |
UniProt Protein Name: | Collagen alpha-5(IV) chain |
Protein Family: | Collagen |
UniProt Gene Name: | COL4A5 |
UniProt Entry Name: | CO4A5_HUMAN |