COG4 Antibody (PACO44993)
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주문- SKU:
- PACO44993
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | COG4 Antibody (PACO44993) |
Antibody SKU: | PACO44993 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Conserved oligomeric Golgi complex subunit 4 protein (506-785AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: COG4 antibody at 4.85µg/ml. Lane 1: Mouse liver tissue. Lane 2: Mouse gonadal tissue. Lane 3: K562 whole cell lysate. Lane 4: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 90, 39, 82 kDa. Observed band size: 90 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44993 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO44993 at dilution of 1:100. |
Background: | Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. |
Synonyms: | Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4), COG4 |
UniProt Protein Function: | COG4: Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Defects in COG4 are the cause of congenital disorder of glycosylation type 2J (CDG2J). It is a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the COG4 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Vesicle; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: Golgi membrane; Golgi transport complex; trans-Golgi network membrane Molecular Function:protein binding Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; Golgi vesicle prefusion complex stabilization; retrograde transport, vesicle recycling within Golgi; retrograde vesicle-mediated transport, Golgi to ER Disease: Congenital Disorder Of Glycosylation, Type Iij |
NCBI Summary: | The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010] |
UniProt Code: | Q9H9E3 |
NCBI GenInfo Identifier: | 311033464 |
NCBI Gene ID: | 25839 |
NCBI Accession: | Q9H9E3.3 |
UniProt Secondary Accession: | Q9H9E3,Q96D40, Q9BRF0, Q9BVZ2, Q9H5Y4, Q9Y3W3, B4DMN8 C9JS23, |
UniProt Related Accession: | Q9H9E3 |
Molecular Weight: | 81,098 Da |
NCBI Full Name: | Conserved oligomeric Golgi complex subunit 4 |
NCBI Synonym Full Names: | component of oligomeric golgi complex 4 |
NCBI Official Symbol: | COG4 |
NCBI Official Synonym Symbols: | COD1; CDG2J |
NCBI Protein Information: | conserved oligomeric Golgi complex subunit 4 |
UniProt Protein Name: | Conserved oligomeric Golgi complex subunit 4 |
UniProt Synonym Protein Names: | Component of oligomeric Golgi complex 4 |
Protein Family: | Conserved oligomeric Golgi complex |
UniProt Gene Name: | COG4 |
UniProt Entry Name: | COG4_HUMAN |