CNTN4 Antibody (PACO03545)
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주문- SKU:
- PACO03545
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CNTN4 Antibody |
Antibody SKU: | PACO03545 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Contactin 4. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | CNTN4; Contactin-4; Brain-derived immunoglobulin superfamily protein 2; BIG-2 |
UniProt Protein Function: | CNTN4: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis. A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features. Belongs to the immunoglobulin superfamily. Contactin family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 3p26.3-p26.2 Cellular Component: extracellular region; plasma membrane Biological Process: axon guidance; axonal fasciculation; axonogenesis; brain development; C-terminal protein lipidation; negative regulation of neuron differentiation; nervous system development; neurite development; neuron adhesion; regulation of synaptic plasticity |
NCBI Summary: | This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011] |
UniProt Code: | Q8IWV2 |
NCBI GenInfo Identifier: | 55976529 |
NCBI Gene ID: | 152330 |
NCBI Accession: | Q8IWV2.1 |
UniProt Secondary Accession: | Q8IWV2,Q8IX14, Q8TC35, B2RAX3, |
UniProt Related Accession: | Q8IWV2 |
Molecular Weight: | 113kDa |
NCBI Full Name: | Contactin-4 |
NCBI Synonym Full Names: | contactin 4 |
NCBI Official Symbol: | CNTN4 |
NCBI Official Synonym Symbols: | AXCAM; BIG-2 |
NCBI Protein Information: | contactin-4 |
UniProt Protein Name: | Contactin-4 |
UniProt Synonym Protein Names: | Brain-derived immunoglobulin superfamily protein 2; BIG-2 |
Protein Family: | Contactin |
UniProt Gene Name: | CNTN4 |