CNOT7 Antibody (PACO00617)
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주문- SKU:
- PACO00617
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CNOT7 Antibody |
Antibody SKU: | PACO00617 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse |
Immunogen: | synthesized peptide derived from the N-terminal region of human CNOT7. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | CNOT7; CAF1; CCR4-NOT transcription complex subunit 7; BTG1-binding factor 1; CCR4-associated factor 1; CAF-1 |
UniProt Protein Function: | CNOT7: Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression. Belongs to the CAF1 family. |
UniProt Protein Details: | Protein type:EC 3.1.13.4; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 8p22-p21.3 Cellular Component: membrane; nucleus; cytosol; CCR4-NOT complex Molecular Function:protein binding; signal transducer activity; 3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; exoribonuclease activity; RNA binding; metal ion binding; transcription factor activity Biological Process: deadenylation-dependent decapping; transcription, DNA-dependent; signal transduction; miRNA-mediated gene silencing; regulation of translation; negative regulation of cell proliferation; poly(A) tail shortening; carbohydrate metabolic process; positive regulation of cell proliferation; gene expression; RNA-mediated gene silencing; positive regulation of transcription from RNA polymerase II promoter; cytoplasmic mRNA processing body assembly; mRNA catabolic process, deadenylation-dependent decay |
NCBI Summary: | The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014] |
UniProt Code: | Q9UIV1 |
NCBI GenInfo Identifier: | 41713629 |
NCBI Gene ID: | 29883 |
NCBI Accession: | Q9UIV1.3 |
UniProt Secondary Accession: | Q9UIV1,Q7Z530, A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108 |
UniProt Related Accession: | Q9UIV1 |
Molecular Weight: | 28,228 Da |
NCBI Full Name: | CCR4-NOT transcription complex subunit 7 |
NCBI Synonym Full Names: | CCR4-NOT transcription complex, subunit 7 |
NCBI Official Symbol: | CNOT7 |
NCBI Official Synonym Symbols: | CAF1; Caf1a; hCAF-1 |
NCBI Protein Information: | CCR4-NOT transcription complex subunit 7; CAF-1; BTG1 binding factor 1; BTG1-binding factor 1; CCR4-associated factor 1; carbon catabolite repressor protein (CCR4)-associative factor 1 |
UniProt Protein Name: | CCR4-NOT transcription complex subunit 7 |
UniProt Synonym Protein Names: | BTG1-binding factor 1; CCR4-associated factor 1; CAF-1; Caf1a |
Protein Family: | CCR4-NOT transcription complex |
UniProt Gene Name: | CNOT7 |
UniProt Entry Name: | CNOT7_HUMAN |