CNNM4 Antibody (PACO61037)
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주문- SKU:
- PACO61037
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CNNM4 Antibody (PACO61037) |
Antibody SKU: | PACO61037 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Metal transporter CNNM4 protein (589-691AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO61037 diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | Immunofluorescence staining of Hela cells with PACO61037 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. |
Synonyms: | Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4), CNNM4, ACDP4 KIAA1592 |
UniProt Protein Function: | CNNM4: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions. May play a role in biomineralization and retinal function. Defects in CNNM4 are the cause of Jalili syndrome (JALIS). A syndrome characterized by the association of cone- rod dystrophy and amelogenesis imperfecta. Belongs to the ACDP family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell cycle regulation; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2q11 Disease: Jalili Syndrome |
NCBI Summary: | This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010] |
UniProt Code: | Q6P4Q7 |
NCBI GenInfo Identifier: | 224471892 |
NCBI Gene ID: | 26504 |
NCBI Accession: | Q6P4Q7.3 |
UniProt Secondary Accession: | Q6P4Q7,Q53RE5, Q9H9G3, Q9HCI0, Q9NRN1, B7Z1U0, C7SQM3 C7SQM4, C7SQM5, |
UniProt Related Accession: | Q6P4Q7 |
Molecular Weight: | 29,485 Da |
NCBI Full Name: | Metal transporter CNNM4 |
NCBI Synonym Full Names: | cyclin and CBS domain divalent metal cation transport mediator 4 |
NCBI Official Symbol: | CNNM4 |
NCBI Official Synonym Symbols: | ACDP4 |
NCBI Protein Information: | metal transporter CNNM4 |
UniProt Protein Name: | Metal transporter CNNM4 |
UniProt Synonym Protein Names: | Ancient conserved domain-containing protein 4; Cyclin-M4 |
Protein Family: | Metal transporter |
UniProt Gene Name: | CNNM4 |
UniProt Entry Name: | CNNM4_HUMAN |
Antibodies |
Anti-CNNM4 Antibody (CAB17130) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |