CLK1 Antibody (PACO44491)
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주문- SKU:
- PACO44491
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CLK1 Antibody (PACO44491) |
Antibody SKU: | PACO44491 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Dual specificity protein kinase CLK1 protein (1-130AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: CLK1antibody at 3.07µg/ml. Lane 1: HepG2 whole cell lysate. Lane 2: Jurkat whole cell lysate. Lane 3: U251 whole cell lysate. Lane 4: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 58, 17, 62 kDa. Observed band size: 58 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44491 at dilution of 1:100. |
Background: | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. |
Synonyms: | Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1), CLK1, CLK |
UniProt Protein Function: | CLK1: a CMGC kinase of the CLK family. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May play a role in regulating RNA splicing. |
UniProt Protein Details: | Protein type:Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; EC 2.7.12.1; Kinase, protein; CMGC group; CLK family Chromosomal Location of Human Ortholog: 2q33 Cellular Component: cytoplasm; nucleus Molecular Function:protein serine/threonine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding Biological Process: cell proliferation; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; regulation of RNA splicing; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation |
NCBI Summary: | This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] |
UniProt Code: | P49759 |
NCBI GenInfo Identifier: | 206729857 |
NCBI Gene ID: | 1195 |
NCBI Accession: | P49759.2 |
UniProt Secondary Accession: | P49759,Q0P694, Q8N5V8, B4DFW7, |
UniProt Related Accession: | P49759 |
Molecular Weight: | 484 |
NCBI Full Name: | Dual specificity protein kinase CLK1 |
NCBI Synonym Full Names: | CDC-like kinase 1 |
NCBI Official Symbol: | CLK1 |
NCBI Official Synonym Symbols: | CLK; STY; CLK/STY |
NCBI Protein Information: | dual specificity protein kinase CLK1; CDC28/CDC2-like kinase; protein tyrosine kinase STY |
UniProt Protein Name: | Dual specificity protein kinase CLK1 |
UniProt Synonym Protein Names: | CDC-like kinase 1 |
Protein Family: | Dual specificity protein kinase |
UniProt Gene Name: | CLK1 |
UniProt Entry Name: | CLK1_HUMAN |