CLDN7 Antibody (PACO03482)
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주문- SKU:
- PACO03482
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CLDN7 Antibody |
Antibody SKU: | PACO03482 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the C-terminal region of human Claudin-7. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | CLDN7; CEPTRL2; CPETRL2; Claudin-7; CLDN-7 |
UniProt Protein Function: | Claudin-7: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: apicolateral plasma membrane; basolateral plasma membrane; integral to membrane; lateral plasma membrane; tight junction Molecular Function:cell adhesion molecule binding; identical protein binding; protein binding; structural molecule activity Biological Process: calcium-independent cell-cell adhesion; negative regulation of apoptosis; negative regulation of cell adhesion; negative regulation of protein homooligomerization; positive regulation of cell proliferation; positive regulation of defense response to virus by host |
NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] |
UniProt Code: | O95471 |
NCBI GenInfo Identifier: | 311033475 |
NCBI Gene ID: | 1366 |
NCBI Accession: | O95471.4 |
UniProt Secondary Accession: | O95471,Q6IPN3, Q7Z4Y7, Q9BVN0, B2R9X7, D3DTP0, |
UniProt Related Accession: | O95471 |
Molecular Weight: | 16,837 Da |
NCBI Full Name: | Claudin-7 |
NCBI Synonym Full Names: | claudin 7 |
NCBI Official Symbol: | CLDN7 |
NCBI Official Synonym Symbols: | CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1 |
NCBI Protein Information: | claudin-7 |
UniProt Protein Name: | Claudin-7 |
Protein Family: | Claudin |
UniProt Gene Name: | CLDN7 |
UniProt Entry Name: | CLD7_HUMAN |