CHRNA5 Antibody (PACO00363)
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주문- SKU:
- PACO00363
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CHRNA5 Antibody |
Antibody SKU: | PACO00363 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat, Monkey |
Immunogen: | synthesized peptide derived from the Internal region of human AChRalpha5. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | CHRNA5; NACHRA5; Neuronal acetylcholine receptor subunit alpha-5 |
UniProt Protein Function: | nAChRA5: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 5/CHRNA5 sub-subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q24 Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; cell junction Molecular Function:acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity Biological Process: synaptic transmission; transport; behavioral response to nicotine; signal transduction; cation transport Disease: Smoking As A Quantitative Trait Locus 3 |
NCBI Summary: | The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010] |
UniProt Code: | P30532 |
NCBI GenInfo Identifier: | 2506126 |
NCBI Gene ID: | 1138 |
NCBI Accession: | P30532.2 |
UniProt Related Accession: | P30532 |
Molecular Weight: | Molecular Mass: 27.6kDaActual Protein Molecular Mass: 35-40kDa |
NCBI Full Name: | Neuronal acetylcholine receptor subunit alpha-5 |
NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 5 subunit |
NCBI Official Symbol: | CHRNA5 |
NCBI Official Synonym Symbols: | LNCR2 |
NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-5 |
UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-5 |
Protein Family: | Neuronal acetylcholine receptor |
UniProt Gene Name: | CHRNA5 |
UniProt Entry Name: | ACHA5_HUMAN |