CHRNA10 Antibody (PACO22466)
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주문- SKU:
- PACO22466
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CHRNA10 Antibody (PACO22466) |
Antibody SKU: | PACO22466 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from C-terminal of human CHRNA10. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from A549 cells, COLO cells, HeLa cells and 293 cells, using CHRNA10 antibody. |
Background: | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. |
Synonyms: | ach10; cholinergic receptor; nicotinic; alpha 10; chrna10 |
UniProt Protein Function: | nAChRA10: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 10/CHRNA10 sub-subfamily. |
UniProt Protein Details: | Protein type:Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: membrane; nicotinic acetylcholine-gated receptor-channel complex Molecular Function:acetylcholine binding; acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; regulation of cell proliferation; synaptic transmission, cholinergic |
UniProt Code: | Q9GZZ6 |
NCBI GenInfo Identifier: | 14916526 |
NCBI Gene ID: | 57053 |
NCBI Accession: | Q9GZZ6.1 |
UniProt Related Accession: | Q9GZZ6 |
Molecular Weight: | 49,705 Da |
NCBI Full Name: | Neuronal acetylcholine receptor subunit alpha-10 |
NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 10 subunit |
NCBI Official Symbol: | CHRNA10 |
NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-10 |
UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-10 |
UniProt Synonym Protein Names: | Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10 |
Protein Family: | Neuronal acetylcholine receptor |
UniProt Gene Name: | CHRNA10 |
UniProt Entry Name: | ACH10_HUMAN |