CHD1 Antibody (PACO43946)
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주문- SKU:
- PACO43946
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- ChIP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CHD1 Antibody (PACO43946) |
Antibody SKU: | PACO43946 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, ChIP |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Chromodomain-helicase-DNA-binding protein 1 protein (1501-1710AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43946 at dilution of 1:100. |
![]() | Chromatin Immunoprecipitation Hela (1.1*106) were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4µg anti-CDH1 or a control normal rabbit IgG. The resulting ChIP DNA was quantified tissue using real-time PCR with primers (PACO43946) against the RPL30 promoter. |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43946 at dilution of 1:100. |
Background: | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. |
Synonyms: | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1), CHD1 |
UniProt Protein Function: | CHD-1: a sequence-selective DNA-binding protein. Contains two chromo (chromatin organization modifier) domains and one SNF2-related helicase and ATPase domains. May play an important role in gene regulation. |
UniProt Protein Details: | Protein type:Helicase; EC 3.6.4.12 Chromosomal Location of Human Ortholog: 5q15-q21 Cellular Component: cytoplasm; nucleus Molecular Function:ATP-dependent DNA helicase activity; protein binding; DNA binding; methylated histone residue binding; ATP binding Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA duplex unwinding |
UniProt Code: | O14646 |
NCBI GenInfo Identifier: | 269849549 |
NCBI Gene ID: | |
NCBI Accession: | O14646.2 |
Molecular Weight: | 197kDa |
NCBI Full Name: | Chromodomain-helicase-DNA-binding protein 1 |
UniProt Protein Name: | Chromodomain-helicase-DNA-binding protein 1 |
UniProt Synonym Protein Names: | ATP-dependent helicase CHD1 |
Protein Family: | Chromodomain-helicase-DNA-binding protein |
UniProt Gene Name: | CHD1 |
UniProt Entry Name: | CHD1_HUMAN |
Antibodies |
Anti-CHD1 Antibody (CAB15038) |
Anti-CHD1 Antibody (CAB7883)[KO Validated] |
CHD1 Antibody (PACO08397) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |