CES3 Antibody (PACO45742)
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주문- SKU:
- PACO45742
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CES3 Antibody (PACO45742) |
Antibody SKU: | PACO45742 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Carboxylesterase 3 protein (65-233AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human appendix tissue using PACO45742 at dilution of 1:100. |
![]() | Immunofluorescent analysis of Hela cells using PACO45742 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO45742 at dilution of 1:100. |
Background: | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. |
Synonyms: | Carboxylesterase 3 (EC 3.1.1.1) (Liver carboxylesterase 31 homolog), CES3 |
UniProt Protein Function: | CES3: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. Belongs to the type-B carboxylesterase/lipase family. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Secreted, signal peptide; Secreted; Hydrolase; EC 3.1.1.1 Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: extracellular space; endoplasmic reticulum lumen Biological Process: metabolic process |
NCBI Summary: | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010] |
UniProt Code: | Q6UWW8 |
NCBI GenInfo Identifier: | 74758561 |
NCBI Gene ID: | 23491 |
NCBI Accession: | Q6UWW8.1 |
UniProt Secondary Accession: | Q6UWW8,Q7Z6J1, Q9H6X7, B2Z3W9, F5H242, |
UniProt Related Accession: | Q6UWW8 |
Molecular Weight: | 24,106 Da |
NCBI Full Name: | Carboxylesterase 3 |
NCBI Synonym Full Names: | carboxylesterase 3 |
NCBI Official Symbol: | CES3 |
NCBI Official Synonym Symbols: | ES31 |
NCBI Protein Information: | carboxylesterase 3; esterase 31; carboxylesterase 3 (brain); liver carboxylesterase 31 homolog |
UniProt Protein Name: | Carboxylesterase 3 |
UniProt Synonym Protein Names: | Liver carboxylesterase 31 homolog |
Protein Family: | Carboxylesterase |
UniProt Gene Name: | CES3 |
UniProt Entry Name: | EST3_HUMAN |