CENPK Antibody (PACO45060)
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주문- SKU:
- PACO45060
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CENPK Antibody (PACO45060) |
Antibody SKU: | PACO45060 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Centromere protein K protein (1-269AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: CENPK antibody at 4.17µg/ml. Lane 1: PC-3 whole cell lysate. Lane 2: 293T whole cell lysate. Lane 3: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human liver tissue using PACO45060 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human skin tissue using PACO45060 at dilution of 1:100. |
Background: | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore. |
Synonyms: | Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33), CENPK, ICEN37 |
UniProt Protein Function: | CENPK: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore. Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with MLL. Belongs to the CENPK family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q12.3 Cellular Component: cytosol; nucleoplasm Molecular Function:protein binding Biological Process: DNA replication-independent nucleosome assembly at centromere; sister chromatid cohesion |
NCBI Summary: | CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9BS16 |
NCBI GenInfo Identifier: | 74732954 |
NCBI Gene ID: | 64105 |
NCBI Accession: | Q9BS16.1 |
UniProt Secondary Accession: | Q9BS16,Q9H4L0, |
UniProt Related Accession: | Q9BS16 |
Molecular Weight: | 31,655 Da |
NCBI Full Name: | Centromere protein K |
NCBI Synonym Full Names: | centromere protein K |
NCBI Official Symbol: | CENPK |
NCBI Official Synonym Symbols: | P33; Solt; CENP-K; FKSG14; AF5alpha |
NCBI Protein Information: | centromere protein K |
UniProt Protein Name: | Centromere protein K |
UniProt Synonym Protein Names: | Interphase centromere complex protein 37; Protein AF-5alpha; p33 |
Protein Family: | Centromere protein |
UniProt Gene Name: | CENPK |
UniProt Entry Name: | CENPK_HUMAN |
Antibodies |
Anti-CENPK Antibody (CAB7627) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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