CDKN2B Antibody (PACO25692)
- SKU:
- PACO25692
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CDKN2B Antibody (PACO25692) |
Antibody SKU: | PACO25692 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cyclin-dependent kinase 4 inhibitor B protein (1-138AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human stomach tissue using PACO25692 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO25692 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO25692 at dilution of 1:100. |
Background: | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-β induced cell cycle arrest. |
Synonyms: | Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B), CDKN2B, MTS2 |
UniProt Protein Function: | p15-INK4B: a potent inhibitor that nteracts strongly with CDK4 and CDK6. Potential effector of TGF-beta induced cell cycle arrest. |
UniProt Protein Details: | Protein type:Tumor suppressor; Protein kinase, regulatory subunit; Cell cycle regulation; Inhibitor Chromosomal Location of Human Ortholog: 9p21 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding Biological Process: cell cycle arrest; cellular response to extracellular stimulus; cellular response to nutrient; G2/M transition of mitotic cell cycle; megakaryocyte differentiation; mitotic cell cycle checkpoint; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cyclin-dependent protein kinase activity |
NCBI Summary: | This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | P42772 |
NCBI GenInfo Identifier: | 1168869 |
NCBI Gene ID: | 1030 |
NCBI Accession: | P42772.1 |
UniProt Secondary Accession: | P42772,O15125, Q6FI09, |
UniProt Related Accession: | P42772,AAB32712 |
Molecular Weight: | 8,078 Da |
NCBI Full Name: | Cyclin-dependent kinase 4 inhibitor B |
NCBI Synonym Full Names: | cyclin dependent kinase inhibitor 2B |
NCBI Official Symbol: | CDKN2B |
NCBI Official Synonym Symbols: | P15; MTS2; TP15; CDK4I; INK4B; p15INK4b |
NCBI Protein Information: | cyclin-dependent kinase 4 inhibitor B |
UniProt Protein Name: | Cyclin-dependent kinase 4 inhibitor B |
UniProt Synonym Protein Names: | Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4B |
Protein Family: | Cyclin-dependent kinase 4 inhibitor |
UniProt Gene Name: | CDKN2B |
UniProt Entry Name: | CDN2B_HUMAN |