CDKAL1 Antibody (PACO22029)
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주문- SKU:
- PACO22029
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CDKAL1 Antibody (PACO22029) |
Antibody SKU: | PACO22029 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Rat |
Immunogen: | Synthesized peptide derived from N-terminal of human CDKAL. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from COLO205 cells, using CDKAL antibody. |
Background: | Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t6A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) at position 37 in tRNAs that read codons beginning with adenine. |
Synonyms: | CDK5 regulatory subunit-associated protein 1-like 1; CDKAL; |
UniProt Protein Function: | CDKAL1: Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Belongs to the methylthiotransferase family. CDKAL1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; EC 2.8.4.5; Enzyme, misc. Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: endoplasmic reticulum membrane; rough endoplasmic reticulum; membrane; integral to membrane Molecular Function:4 iron, 4 sulfur cluster binding; metal ion binding Disease: Diabetes Mellitus, Noninsulin-dependent |
NCBI Summary: | The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010] |
UniProt Code: | Q5VV42 |
NCBI GenInfo Identifier: | 74747199 |
NCBI Gene ID: | 54901 |
NCBI Accession: | Q5VV42.1 |
UniProt Secondary Accession: | Q5VV42,Q6P385, Q6ZR27, Q9NXB3, A8K6S0, |
UniProt Related Accession: | Q5VV42 |
Molecular Weight: | 579 |
NCBI Full Name: | Threonylcarbamoyladenosine tRNA methylthiotransferase |
NCBI Synonym Full Names: | CDK5 regulatory subunit associated protein 1-like 1 |
NCBI Official Symbol: | CDKAL1 |
NCBI Protein Information: | threonylcarbamoyladenosine tRNA methylthiotransferase; tRNA-t(6)A37 methylthiotransferase |
UniProt Protein Name: | Threonylcarbamoyladenosine tRNA methylthiotransferase |
UniProt Synonym Protein Names: | CDK5 regulatory subunit-associated protein 1-like 1; tRNA-t(6)A37 methylthiotransferase |
Protein Family: | Threonylcarbamoyladenosine tRNA methylthiotransferase |
UniProt Gene Name: | CDKAL1 |
UniProt Entry Name: | CDKAL_HUMAN |