CDC42BPA Antibody (PACO22802)
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주문- SKU:
- PACO22802
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CDC42BPA Antibody (PACO22802) |
Antibody SKU: | PACO22802 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:200, IF:1:100-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from Internal of human MRCKa. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from Jurkat/COLO205 cells, using MRCKa antibody. |
Background: | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. |
Synonyms: | CDC42 binding protein kinase alpha (DMPK-like); CDC42 binidng protein kinase beta; CDC42-binding protein kinase alpha; CDC42-binding protein kinase alpha (DMPK-like); CDC42BPA |
UniProt Protein Function: | MRCKA: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; DMPK family; GEK subfamily Chromosomal Location of Human Ortholog: 1q42.11 Cellular Component: cytoplasm; leading edge; actomyosin; intercellular junction Molecular Function:identical protein binding; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding Biological Process: cell migration; regulation of catalytic activity; actomyosin structure organization and biogenesis; actin cytoskeleton reorganization; microtubule cytoskeleton organization and biogenesis; nuclear migration; protein amino acid phosphorylation |
NCBI Summary: | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018] |
UniProt Code: | Q5VT25 |
NCBI GenInfo Identifier: | 30089962 |
NCBI Gene ID: | 8476 |
NCBI Accession: | NP_003598.2 |
UniProt Related Accession: | Q5VT25 |
Molecular Weight: | |
NCBI Full Name: | serine/threonine-protein kinase MRCK alpha isoform B |
NCBI Synonym Full Names: | CDC42 binding protein kinase alpha |
NCBI Official Symbol: | CDC42BPA |
NCBI Official Synonym Symbols: | MRCK; MRCKA; PK428 |
NCBI Protein Information: | serine/threonine-protein kinase MRCK alpha |
UniProt Protein Name: | Serine/threonine-protein kinase MRCK alpha |
UniProt Synonym Protein Names: | CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha |
UniProt Gene Name: | CDC42BPA |
UniProt Entry Name: | MRCKA_HUMAN |