UniProt Protein Function: | CDC37: a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases. |
UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: protein complex; cytoplasm; cytosol Molecular Function:protein kinase B binding; protein binding; chaperone binding; heat shock protein binding; unfolded protein binding; mitogen-activated protein kinase kinase kinase binding; Hsp90 protein binding; kinase binding Biological Process: protein folding; protein stabilization; regulation of cyclin-dependent protein kinase activity; protein targeting |
NCBI Summary: | The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16543 |
NCBI GenInfo Identifier: | 21542000 |
NCBI Gene ID: | 11140 |
NCBI Accession: | Q16543.1 |
UniProt Secondary Accession: | Q16543,Q53YA2, |
UniProt Related Accession: | Q16543 |
Molecular Weight: | 378 |
NCBI Full Name: | Hsp90 co-chaperone Cdc37 |
NCBI Synonym Full Names: | cell division cycle 37 |
NCBI Official Symbol: | CDC37 |
NCBI Official Synonym Symbols: | P50CDC37 |
NCBI Protein Information: | hsp90 co-chaperone Cdc37; cell division cycle 37 homolog; CDC37 cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; CDC37 (cell division cycle 37, S. cerevisiae, homolog) |
UniProt Protein Name: | Hsp90 co-chaperone Cdc37 |
UniProt Synonym Protein Names: | Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37Hsp90 co-chaperone Cdc37, N-terminally processed |
Protein Family: | Hsp90 co-chaperone |
UniProt Gene Name: | CDC37 |
UniProt Entry Name: | CDC37_HUMAN |