CCR7 Antibody (PACO53974)
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주문- SKU:
- PACO53974
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CCR7 Antibody (PACO53974) |
Antibody SKU: | PACO53974 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human C-C chemokine receptor type 7 protein (332-378AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry analysis of human lung tissue using PACO53974 at dilution of 1:100. |
![]() | Immunofluorescent analysis of Hela cells using PACO53974 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunocytochemistry analysis of human tonsil tissue using PACO53974 at dilution of 1:100. |
Background: | Receptor for the MIP-3-β chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. |
Synonyms: | C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 β receptor) (CD antigen CD197), CCR7, CMKBR7 EBI1 EVI1 |
UniProt Protein Function: | CCR7: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q12-q21.2 Cellular Component: cell surface; plasma membrane; integral to membrane; intracellular; external side of plasma membrane Molecular Function:G-protein coupled receptor activity; C-C chemokine receptor activity Biological Process: positive regulation of cell adhesion; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; positive regulation of JNK cascade; response to lipopolysaccharide; elevation of cytosolic calcium ion concentration; positive regulation of T cell receptor signaling pathway; positive regulation of humoral immune response; dendritic cell chemotaxis; establishment of T cell polarity; positive regulation of cell-matrix adhesion; inflammatory response; positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of hypersensitivity; positive regulation of phosphoinositide 3-kinase activity; negative thymic T cell selection; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; myeloid dendritic cell chemotaxis; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; ruffle organization and biogenesis; regulation of interleukin-1 beta secretion; immune response |
NCBI Summary: | The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
UniProt Code: | P32248 |
NCBI GenInfo Identifier: | 1352335 |
NCBI Gene ID: | 1236 |
NCBI Accession: | P32248.2 |
UniProt Related Accession: | P32248 |
Molecular Weight: | 378 |
NCBI Full Name: | C-C chemokine receptor type 7 |
NCBI Synonym Full Names: | chemokine (C-C motif) receptor 7 |
NCBI Official Symbol: | CCR7 |
NCBI Official Synonym Symbols: | BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7 |
NCBI Protein Information: | C-C chemokine receptor type 7; MIP-3 beta receptor; CC chemokine receptor 7; Bukitt's lymphoma receptor 2; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; Epstein-Barr virus-induced G-protein coupled receptor 1 |
UniProt Protein Name: | C-C chemokine receptor type 7 |
UniProt Synonym Protein Names: | BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD_antigen: CD197 |
Protein Family: | C-C chemokine receptor |
UniProt Gene Name: | CCR7 |
UniProt Entry Name: | CCR7_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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