CCNA1 Antibody (PACO14308)
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주문- SKU:
- PACO14308
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CCNA1 Antibody (PACO14308) |
Antibody SKU: | PACO14308 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:20-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human CCNA1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO14308(CCNA1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | cyclin A1 |
UniProt Protein Function: | CCNA1: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Belongs to the cyclin family. Cyclin AB subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cancer Testis Antigen (CTA); Cell cycle regulation; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 13q12.3-q13 Cellular Component: nucleoplasm; microtubule cytoskeleton; cytosol Molecular Function:protein binding; protein kinase binding Biological Process: G1/S-specific transcription in mitotic cell cycle; mitosis; male meiosis I; cell division; regulation of G2/M transition of mitotic cell cycle; spermatogenesis; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle |
NCBI Summary: | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P78396 |
NCBI GenInfo Identifier: | 8134359 |
NCBI Gene ID: | 8900 |
NCBI Accession: | P78396.1 |
UniProt Secondary Accession: | P78396,Q5T3V0, Q5U0G2, Q8IY91, B7Z7E3, |
UniProt Related Accession: | P78396 |
Molecular Weight: | 465 |
NCBI Full Name: | Cyclin-A1 |
NCBI Synonym Full Names: | cyclin A1 |
NCBI Official Symbol: | CCNA1 |
NCBI Official Synonym Symbols: | CT146 |
NCBI Protein Information: | cyclin-A1 |
UniProt Protein Name: | Cyclin-A1 |
Protein Family: | Cyclin |
UniProt Gene Name: | CCNA1 |
UniProt Entry Name: | CCNA1_HUMAN |
Antibodies | ELISA Kits |
Anti-Cyclin A1 Antibody (CAB14529) | Cyclin A1 Colorimetric Cell-Based ELISA Kit |
Anti-Cyclin A1 Antibody (CAB5631) | |
CCNA1 Antibody (PACO06390) | |
CCNA1 Antibody (PACO08242) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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