CCM2 Antibody (PACO44319)
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주문- SKU:
- PACO44319
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CCM2 Antibody (PACO44319) |
Antibody SKU: | PACO44319 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cerebral cavernous malformations 2 protein (1-300AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human cervical cancer using PACO44319 at dilution of 1:100. |
Background: | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). |
Synonyms: | Cerebral cavernous malformations 2 protein (Malcavernin), CCM2, C7orf22 |
UniProt Protein Function: | CCM2: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock. Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2). Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 7p13 Cellular Component: protein complex; cytoplasm Molecular Function:protein binding Biological Process: integrin-mediated signaling pathway; intercellular junction assembly and maintenance; pericardium development; venous blood vessel morphogenesis; in utero embryonic development; multicellular organism growth; stress-activated MAPK cascade; vasculogenesis; inner ear development; endothelial cell development Disease: Cerebral Cavernous Malformations 2 |
NCBI Summary: | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] |
UniProt Code: | Q9BSQ5 |
NCBI GenInfo Identifier: | 74733042 |
NCBI Gene ID: | 83605 |
NCBI Accession: | Q9BSQ5.1 |
UniProt Secondary Accession: | Q9BSQ5,Q71RE5, Q8TAT4, A4D2L4, B3KUV0, D3DVL4, E9PDJ3 F5H0E1, F5H551, |
UniProt Related Accession: | Q9BSQ5 |
Molecular Weight: | 444 |
NCBI Full Name: | Malcavernin |
NCBI Synonym Full Names: | cerebral cavernous malformation 2 |
NCBI Official Symbol: | CCM2 |
NCBI Official Synonym Symbols: | OSM; C7orf22; PP10187 |
NCBI Protein Information: | malcavernin; cerebral cavernous malformations 2 protein |
UniProt Protein Name: | Malcavernin |
UniProt Synonym Protein Names: | Cerebral cavernous malformations 2 protein |
Protein Family: | Cerebral cavernous malformations protein |
UniProt Gene Name: | CCM2 |
UniProt Entry Name: | CCM2_HUMAN |
Antibodies |
Anti-CCM2 Antibody (CAB6544) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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