CCAR1 Antibody (PACO43270)
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주문- SKU:
- PACO43270
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CCAR1 Antibody (PACO43270) |
Antibody SKU: | PACO43270 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cell division cycle and apoptosis regulator protein 1 protein (1-200AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: CCAR1 antibody at 10µg/ml. Lane 1: Hela whole cell lysate. Lane 2: PC-3 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 133, 132 kDa. Observed band size: 133 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43270 at dilution of 1:100. |
Background: | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. |
Synonyms: | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain), CCAR1, CARP1 DIS |
UniProt Protein Function: | CCAR1: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Apoptosis; RNA splicing Chromosomal Location of Human Ortholog: 10q21.3 Cellular Component: nucleoplasm; perinuclear region of cytoplasm Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity Biological Process: nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; RNA splicing; gene expression; cell cycle |
UniProt Code: | Q8IX12 |
NCBI GenInfo Identifier: | 94707499 |
NCBI Gene ID: | 55749 |
NCBI Accession: | Q8IX12.2 |
UniProt Secondary Accession: | Q8IX12,Q32NE3, Q5EBM3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4 A0JLT7, A1L4P7, A8K9D4, B4DNP8, B4DRK8, |
UniProt Related Accession: | Q8IX12 |
Molecular Weight: | 1150 |
NCBI Full Name: | Cell division cycle and apoptosis regulator protein 1 |
NCBI Synonym Full Names: | cell division cycle and apoptosis regulator 1 |
NCBI Official Symbol: | CCAR1 |
NCBI Protein Information: | cell division cycle and apoptosis regulator protein 1; death inducer with SAP domain; cell cycle and apoptosis regulatory protein 1 |
UniProt Protein Name: | Cell division cycle and apoptosis regulator protein 1 |
UniProt Synonym Protein Names: | Cell cycle and apoptosis regulatory protein 1; CARP-1; Death inducer with SAP domain |
Protein Family: | Cell division cycle and apoptosis regulator protein |
UniProt Gene Name: | CCAR1 |
UniProt Entry Name: | CCAR1_HUMAN |