CAPZB Antibody (PACO43989)
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주문- SKU:
- PACO43989
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CAPZB Antibody (PACO43989) |
Antibody SKU: | PACO43989 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human F-actin-capping protein subunit β protein (1-272AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: CAPZB antibody at 6µg/ml. Lane 1: 293T whole cell lysate. Lane 2: A431 whole cell lysate. Lane 3: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 32, 31 kDa. Observed band size: 32, 31 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO43989 at dilution of 1:100. |
Background: | F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. |
Synonyms: | F-actin-capping protein subunit β (CapZ beta), CAPZB |
UniProt Protein Function: | CAPZB: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Belongs to the F-actin-capping protein beta subunit family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p36.1 Cellular Component: actin cytoskeleton; actin filament; cytoskeleton; cytosol Molecular Function:actin binding; actin filament binding Biological Process: barbed-end actin filament capping; blood coagulation; cell motility; cytoskeleton organization and biogenesis; negative regulation of filopodium formation; regulation of cell morphogenesis |
NCBI Summary: | This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013] |
UniProt Code: | P47756 |
NCBI GenInfo Identifier: | 13124696 |
NCBI Gene ID: | 832 |
NCBI Accession: | P47756.4 |
UniProt Secondary Accession: | P47756,Q32Q68, Q5U0L4, Q8TB49, Q9NUC4, |
UniProt Related Accession: | P47756 |
Molecular Weight: | – Da |
NCBI Full Name: | F-actin-capping protein subunit beta |
NCBI Synonym Full Names: | capping actin protein of muscle Z-line beta subunit |
NCBI Official Symbol: | CAPZB |
NCBI Official Synonym Symbols: | CAPB; CAPZ; CAPPB |
NCBI Protein Information: | F-actin-capping protein subunit beta |
UniProt Protein Name: | F-actin-capping protein subunit beta |
UniProt Synonym Protein Names: | CapZ beta |
Protein Family: | F-actin-capping protein |
UniProt Gene Name: | CAPZB |
UniProt Entry Name: | CAPZB_HUMAN |
Antibodies |
Anti-CAPZB Antibody (CAB8106) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |