CAPN6 Antibody (PACO42886)
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주문- SKU:
- PACO42886
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CAPN6 Antibody (PACO42886) |
Antibody SKU: | PACO42886 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Calpain-6 protein (195-494AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CAPN6 antibody at 5µg/ml + Human placenta tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 75 kDa. Observed band size: 75 kDa. | |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO42886 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human lung tissue using PACO42886 at dilution of 1:100. |
Background: | Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. |
Synonyms: | Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM), CAPN6, CALPM CANPX |
UniProt Protein Function: | CAPN6: Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. Belongs to the peptidase C2 family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: Xq23 Cellular Component: spindle microtubule; perinuclear region of cytoplasm Molecular Function:microtubule binding; calcium-dependent cysteine-type endopeptidase activity Biological Process: proteolysis; microtubule bundle formation; regulation of cytoskeleton organization and biogenesis |
NCBI Summary: | Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009] |
UniProt Code: | Q9Y6Q1 |
NCBI GenInfo Identifier: | 13959315 |
NCBI Gene ID: | 827 |
NCBI Accession: | Q9Y6Q1.2 |
UniProt Related Accession: | Q9Y6Q1 |
Molecular Weight: | |
NCBI Full Name: | Calpain-6 |
NCBI Synonym Full Names: | calpain 6 |
NCBI Official Symbol: | CAPN6 |
NCBI Official Synonym Symbols: | CANPX; CAPNX; CalpM; DJ914P14.1 |
NCBI Protein Information: | calpain-6 |
UniProt Protein Name: | Calpain-6 |
UniProt Synonym Protein Names: | Calpain-like protease X-linked; Calpamodulin; CalpM |
UniProt Gene Name: | CAPN6 |
UniProt Entry Name: | CAN6_HUMAN |
Antibodies | ELISA Kits |
Anti-CAPN6 Antibody (CAB13777) | Human CAPN6 / Calpain 6 ELISA Kit |
CAPN6 Antibody (PACO08173) | Human Calpain-6 (CAPN6) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |