CAPG Antibody (PACO15274)
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주문- SKU:
- PACO15274
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CAPG Antibody (PACO15274) |
Antibody SKU: | PACO15274 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human CAPG |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO15274(CAPG Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, RAW264.7 cells, Primary antibody: PACO15274(CAPG Antibody) at dilution 1/950, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15274(CAPG Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. |
Synonyms: | Capping protein (actin filament), gelsolin-like |
UniProt Protein Function: | CAPG: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Belongs to the villin/gelsolin family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2p11.2 Cellular Component: F-actin capping protein complex; melanosome; nucleus Molecular Function:actin binding Biological Process: protein complex assembly; cell projection biogenesis; barbed-end actin filament capping |
NCBI Summary: | This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012] |
UniProt Code: | P40121 |
NCBI GenInfo Identifier: | 313104088 |
NCBI Gene ID: | 822 |
NCBI Accession: | P40121.2 |
UniProt Secondary Accession: | P40121,Q53SA7, B8ZZS7, D6W5K8, |
UniProt Related Accession: | P40121 |
Molecular Weight: | 348 |
NCBI Full Name: | Macrophage-capping protein |
NCBI Synonym Full Names: | capping protein (actin filament), gelsolin-like |
NCBI Official Symbol: | CAPG |
NCBI Official Synonym Symbols: | MCP; AFCP; HEL-S-66 |
NCBI Protein Information: | macrophage-capping protein; macrophage capping protein; gelsolin-like capping protein; actin regulatory protein CAP-G; actin-regulatory protein CAP-G; epididymis secretory protein Li 66 |
UniProt Protein Name: | Macrophage-capping protein |
UniProt Synonym Protein Names: | Actin regulatory protein CAP-G |
Protein Family: | Protein |
UniProt Gene Name: | CAPG |
UniProt Entry Name: | CAPG_HUMAN |