CAMLG Antibody (PACO53230)
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주문- SKU:
- PACO53230
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CAMLG Antibody (PACO53230) |
Antibody SKU: | PACO53230 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:500, IP:1:200-1:2000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Calcium signal-modulating cyclophilin ligand protein (1-189AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Jurkat whole cell lysate, HEK293 whole cell lysate, U87 whole cell lysate, SH-SY5Y whole cell lysate. All lanes: CAMLG antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 33 kDa. Observed band size: 33 kDa. |
![]() | Immunoprecipitating CAMLG in HEK293 whole cell lysate. Lane 1: Rabbit control IgG (1µg) instead of PACO53230 in HEK293 whole cell lysate.For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000). Lane 2: PACO53230 (8µg) + HEK293 whole cell lysate (500µg). Lane 3: HEK293 whole cell lysate (10µg). |
![]() | Immunofluorescent analysis of HepG2 cells using PACO53230 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. |
Synonyms: | Calcium signal-modulating cyclophilin ligand (CAML), CAMLG, CAML |
UniProt Protein Function: | CAMLG: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 5q23 Cellular Component: membrane; endoplasmic reticulum; integral to membrane Molecular Function:protein binding; cell adhesion molecule binding Biological Process: receptor recycling; epidermal growth factor receptor signaling pathway; viral reproduction; defense response; signal transduction |
NCBI Summary: | The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49069 |
NCBI GenInfo Identifier: | 4502559 |
NCBI Gene ID: | 819 |
NCBI Accession: | NP_001736.1 |
UniProt Secondary Accession: | P49069,P49070, |
UniProt Related Accession: | P49069 |
Molecular Weight: | 32,953 Da |
NCBI Full Name: | calcium signal-modulating cyclophilin ligand |
NCBI Synonym Full Names: | calcium modulating ligand |
NCBI Official Symbol: | CAMLG |
NCBI Official Synonym Symbols: | CAML |
NCBI Protein Information: | calcium signal-modulating cyclophilin ligand; calcium-modulating cyclophilin ligand; calcium-signal modulating cyclophilin ligand; cyclophilin B-binding protein |
UniProt Protein Name: | Calcium signal-modulating cyclophilin ligand |
UniProt Gene Name: | CAMLG |
UniProt Entry Name: | CAMLG_HUMAN |
Antibodies |
Anti-CAMLG Antibody (CAB13720) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |