CALHM1 Antibody (PACO43486)
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주문- SKU:
- PACO43486
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CALHM1 Antibody (PACO43486) |
Antibody SKU: | PACO43486 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Calcium homeostasis modulator protein 1 protein (202-346AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human liver cancer using PACO43486 at dilution of 1:100. |
Background: | Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-β (Abeta) peptides levels in a Ca2+ dependent manner. |
Synonyms: | Calcium homeostasis modulator protein 1 (Protein FAM26C), CALHM1, FAM26C |
UniProt Protein Function: | CALHM1: May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. Belongs to the FAM26 family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium Chromosomal Location of Human Ortholog: 10q24.33 Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane Molecular Function:calcium activated cation channel activity; identical protein binding; voltage-gated calcium channel activity; voltage-gated ion channel activity Biological Process: ATP transport; cation transport; protein homooligomerization; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste |
NCBI Summary: | This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010] |
UniProt Code: | Q8IU99 |
NCBI GenInfo Identifier: | 68565595 |
NCBI Gene ID: | 255022 |
NCBI Accession: | Q8IU99.2 |
UniProt Secondary Accession: | Q8IU99,Q5W091, |
UniProt Related Accession: | Q8IU99 |
Molecular Weight: | 38,264 Da |
NCBI Full Name: | Calcium homeostasis modulator protein 1 |
NCBI Synonym Full Names: | calcium homeostasis modulator 1 |
NCBI Official Symbol: | CALHM1 |
NCBI Official Synonym Symbols: | FAM26C |
NCBI Protein Information: | calcium homeostasis modulator protein 1 |
UniProt Protein Name: | Calcium homeostasis modulator protein 1 |
UniProt Synonym Protein Names: | Protein FAM26C |
Protein Family: | Calcium homeostasis modulator protein |
UniProt Gene Name: | CALHM1 |
UniProt Entry Name: | CAHM1_HUMAN |