CACNA1D Antibody (PACO62411)
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주문- SKU:
- PACO62411
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CACNA1D Antibody (PACO62411) |
Antibody SKU: | PACO62411 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Voltage-dependent L-type calcium channel subunit alpha-1D protein (1691-1806AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescence staining of MCF-7 cells with PACO62411 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). |
Synonyms: | Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Voltage-gated calcium channel subunit α Cav1.3), CACNA1D, CACH3 CACN4 CACNL1A2 CCHL1A2 |
UniProt Protein Function: | CACNA1D: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium Chromosomal Location of Human Ortholog: 3p14.3 Cellular Component: plasma membrane; voltage-gated calcium channel complex; Z disc Molecular Function:voltage-gated calcium channel activity; metal ion binding; high voltage-gated calcium channel activity; ankyrin binding; alpha-actinin binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; axon guidance; sensory perception of sound; calcium ion transport; energy reserve metabolic process; positive regulation of calcium ion transport; regulation of insulin secretion Disease: Primary Aldosteronism, Seizures, And Neurologic Abnormalities; Sinoatrial Node Dysfunction And Deafness |
NCBI Summary: | Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] |
UniProt Code: | Q01668 |
NCBI GenInfo Identifier: | 116241275 |
NCBI Gene ID: | 776 |
NCBI Accession: | Q01668.2 |
UniProt Related Accession: | Q01668 |
Molecular Weight: | |
NCBI Full Name: | Voltage-dependent L-type calcium channel subunit alpha-1D |
NCBI Synonym Full Names: | calcium voltage-gated channel subunit alpha1 D |
NCBI Official Symbol: | CACNA1D |
NCBI Official Synonym Symbols: | CACH3; CACN4; PASNA; SANDD; Cav1.3; CCHL1A2; CACNL1A2 |
NCBI Protein Information: | voltage-dependent L-type calcium channel subunit alpha-1D |
UniProt Protein Name: | Voltage-dependent L-type calcium channel subunit alpha-1D |
UniProt Synonym Protein Names: | Calcium channel, L type, alpha-1 polypeptide, isoform 2; Voltage-gated calcium channel subunit alpha Cav1.3 |
UniProt Gene Name: | CACNA1D |
UniProt Entry Name: | CAC1D_HUMAN |