C5AR2 Antibody (PACO62099)
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주문- SKU:
- PACO62099
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | C5AR2 Antibody (PACO62099) |
Antibody SKU: | PACO62099 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Peptide sequence from Human C5a anaphylatoxin chemotactic receptor 2 protein (2-19AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO62099 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO62099 diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. |
Synonyms: | C5a anaphylatoxin chemotactic receptor 2 (Complement component 5a receptor 2) (G-protein coupled receptor 77), C5AR2, C5L2 GPR77 |
UniProt Protein Function: | C5AR2: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: apical part of cell; basal plasma membrane; integral to plasma membrane; plasma membrane Molecular Function:complement component C5a receptor activity; G-protein coupled receptor activity; protein binding Biological Process: elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inflammatory response; negative regulation of tumor necrosis factor production; regulation of complement activation |
NCBI Summary: | This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] |
UniProt Code: | Q9P296 |
NCBI GenInfo Identifier: | 20137533 |
NCBI Gene ID: | 27202 |
NCBI Accession: | Q9P296.1 |
UniProt Secondary Accession: | Q9P296,B2RA09, |
UniProt Related Accession: | Q9P296 |
Molecular Weight: | Calculated: 36 kDaObserved: 36 kDa |
NCBI Full Name: | C5a anaphylatoxin chemotactic receptor 2 |
NCBI Synonym Full Names: | complement component 5a receptor 2 |
NCBI Official Symbol: | C5AR2 |
NCBI Official Synonym Symbols: | C5L2; GPF77; GPR77 |
NCBI Protein Information: | C5a anaphylatoxin chemotactic receptor 2 |
UniProt Protein Name: | C5a anaphylatoxin chemotactic receptor 2 |
UniProt Synonym Protein Names: | Complement component 5a receptor 2; G-protein coupled receptor 77 |
Protein Family: | C5a anaphylatoxin chemotactic receptor |
UniProt Gene Name: | C5AR2 |
Antibodies |
Anti-C5AR2 Antibody (CAB10588) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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